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Excessive copper binds selectively to lipoylated proteins involved in the tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and cell death by increasing ROS [170, 171]

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Metformin reduces glucose synthesis in the liver, reduces glucose absorption in the intestine, and increases insulin sensitivity by enhancing peripheral glucose uptake and utilization

Mehandru and Merad reviewed the many clinical manifestations of long-haul COVID, including systemic and musculoskeletal manifestations (chronic fatigue and fibromyalgia symptoms), psychiatric symptoms (insomnia, depression, anxiety, neurocognitive deficits), autonomic and cardiovascular, GIS and renal and respiratory manifestations [71]