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Shuo Hu, [email protected] These authors have contributed equally to this work This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The more common presentation is in a preexisting acquired or congenital nevus in which a focal bluish discoloration raises the possibility of malignant degeneration

Also, NRP1 (but not ACE2) serves as the principal CSR to mediate SARS-CoV-2 infection of astrocytes in the brain tissue