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Concentrations of the active intact hormones are increased by sitagliptin, thereby increasing and prolonging the action of these hormones

The engagement of the glucagon receptor, in addition to GLP-1 and GIP, appears to drive its pronounced effects on weight and metabolic parameters

[95% CI 0.571.11]

One example is retatrutide, a triple agonist targeting GLP-1, GIP, and glucagon receptors, which demonstrated statistically significant weight loss (22.8-24.2%) and metabolic improvements in systolic and diastolic blood pressure and levels of glycated hemoglobin, fasting glucose, insulin, and lipids in a 48-week phase 2 trial, highlighting its potential for future obesity management