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As previously demonstrated during Tylenol overdose cases, the pharmacokinetics of NAC as a glutathione donor also have the potential to improve the negative toxic effects of acetaldehyde when excess alcohol is consumed 4

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Explore novel modalities such as PROTACs (targeting ACSL4 and Nrf2), gene therapies (e.g., AAV-mediated SLC7A11 overexpression in PT cells), and epigenetic modulators (e.g., m 6 A inhibitors that regulate ferroptosis-related gene expression)

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