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The ongoing clinical trial, the Restoring Insulin Secretion (RISE) Consortium, is testing whether placebo, metformin alone, liraglutide plus metformin, or insulin (3 months) followed by metformin (9 months) can preserve or improve beta cell function in individuals with early type 2 diabetes or prediabetes 48

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While the National Institutes of Health (NIH) supports the clinical benefits of these medications, the economic argument has not translated into the sweeping coverage expansion that patients need

As the body sheds fat mass, resting metabolic rate typically decreases by 1020%, a phenomenon called adaptive thermogenesis