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The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

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both have been researched for their proposed affinity for receptors in the pituitary gland and other parts of the central nervous system

NAD+ helps improve energy at the cellular level, and B12 helps with fatigue from deficiencies