To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: (Young et al., 1990) an oxidative stress module linking Gpx3 with glutathione metabolites, and ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature
Understanding the Master Antioxidant Glutathione is a tripeptide made of three amino acids: cysteine, glycine, and glutamate
This is potentially completed by reducing oxidative damage to tissues in your heart, which can reduce the likelihood of heart disease, strokes, heart attacks and other serious conditions
Fibroblast: A type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing
