Talk to your healthcare provider and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug
Overview Phase I metabolism oxidation (via cytochrome P450), reduction, and hydrolysis reactions phase I reactions convert a parent drug to more polar (water soluble) active metabolites by unmasking or inserting a polar functional group (-OH, -SH, -NH2) geriatric patients have decreased phase I metabolism drugs metabolized via phase I reactions have longer half-lives geriatric patients metabolism drugs by phase II reactions Phase II metabolism glucuronidation, acetylation, and sulfation reactions conjugation reactions that increase water solubility of drug with a polar moiety glucuronate, acetate, and sulfate, respectively phase II reactions convert a parent drug to more polar (water soluble) inactive metabolites by conjugation of subgroups to -OH, -SH, -NH2 functional groups on drug drugs metabolized via phase II reactions are renally excreted patients deficient in acetylation capacity (slow acetylators) may have prolonged or toxic responses to normal doses of certain drugs because of decreased rates of metabolism What is Phase I Metabolism
Storing peptides in plastic syringes for extended periods can sometimes lead to adsorption and a decrease in potency
On top of that, glutathione helps to balance inflammatory reactions, supports detoxification and aids in protection of cells, tissues and organs
