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[1] [2] Routine consultation with a healthcare provider is appropriate when: Bloating persists beyond 2-3 weeks despite dietary modifications and dose stabilization Symptoms significantly impair quality of life or daily functioning Bloating is accompanied by persistent nausea, early satiety, or regurgitation, which may suggest severe gastroparesis New or worsening heartburn or reflux symptoms develop There is concern about medication interactions or the need for dose adjustment Healthcare providers should evaluate for potential complications of tirzepatide therapy, including acute pancreatitis (characterized by severe epigastric pain radiating to the back, nausea, and elevated lipase levels) and severe gastroparesis

the one I am talking about in this video is estradiol (E 2 )

Prog Cardiovasc Dis 1997

Gynecol Endocrinol 2019;35(8):701-5