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However, one of aleglitazar phase 3 trials (NCT01042769) was terminated because of cardiovascular issues

Int J Mol Sci 11(11):44654487

Trimethylglycine is given orally in a small amount of water to provide additional methyl groups needed to help NAD+ function better.* NAD+ IV therapy takes longer to administer than other IV drips from 2 to 6 hours, depending on your dose and tolerance