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A note on compounding pharmacies: Due to current drug shortages, the FDA has permitted certain state-licensed compounding pharmacies to create custom versions of semaglutide

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AE adverse event, BMI body mass index, CI confidence interval, FDA Food and Drug Administration, HR hazard ratio, T2D type 2 diabetes Mechanism of Action, Safety, and Efficacy Semaglutide exerts its effects through both central and peripheral pathways, replicating and enhancing the physiological actions of endogenous GLP-1 [35]