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GLP-1s can help bypass some of these metabolic hurdles

Compared to traditional imaging methods, PET offers unique advantages in studying cellular metabolism, including higher spatial resolution and sensitivity

It's harder to put hormones on the receptor, and so that's what happens with insulin [00:10:00] resistance

Moreover, the FINEARTS-HF trial showed that compared with placebo, finerenone resulted in a significant reduction in worsening heart failure events and cardiovascular death in patients with left ventricular ejection fraction 40%.88 These findings extend the utility of finerenone beyond CKD management, reinforcing its broad applicability across cardiometabolic and heart failure syndromes