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In a large-scale study conducted in adult epilepsy patients in Japan, HA was found in 43% of the cohort, with 40.7% of them presenting with symptomatic HA requiring treatment with carnitine rescue, intravenous therapy or VPA dose reduction [6]

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The root of the tongue connects it to the jaw and to the hyoid bone, while the body stores on its surface four distinct lingual papillae, each with a unique anatomical and functional characteristic and an individual relationship with taste perception ( Figure 1 ) It is also important to highlight the complex neuronal architecture of the tongue, as we should consider three different innervation types: 1) Autonomic innervation: generates the salivatory stimuli and regulation of local blood flow, that plays an important role in food pleasure and avoidance ( C, A-, and A- fibers (30)