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Tolerance can be dangerous, as BAC still rises at the same rate even if a person doesnt feel the effects

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Incorrect transesterification of L- O -Val-L-Val- S -PCP ( DP2b ) to the TE domain, followed by C* domain catalyzed esterification with one or two units of tetradepsipeptidyl-S-PCP gives rise to the TE-bound hexadepsipeptide (L- O -Val-L-Val-D- O -Leu-D-Ala)-L- O -Val-L-Val- O -TE ( DP6b ) and decadepsipeptide (L- O -Val-L-Val-D- O -Leu-D-Ala) 2 -L- O -Val-L-Val- O -TE ( DP10b ), respectively

[PMC free article: PMC293153] [PubMed: 13631057] 472