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Critically, low doses (approximately 5x baseline levels) were effective while high doses were not, suggesting a therapeutic window

The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) among Sudanese patients

Deletion of Pde3a and Pde3b in PASMCs can inhibit mitochondrial oxidative phosphorylation and enhance glycolysis by downregulating the AMPK/CREB signal and upregulating PDK1/2/4 ( The metabolic reprogramming of PASMCs is mainly driven by chronic hypoxia, which upregulates adenylate kinase 4 (AK4) in a HIF-1-dependent manner

Thus, the melatonin rhythm provides both clock and calendar information (32)