why do some people not lose weight on glp 1 GLP-1 for Loss and Diabetes GLP-1 Medications for Weight Loss:

In 2004, researchers conducted a meta-analysis of 61 randomized controlled trials evaluating GLP-1 RAs, sodium-glucose co-transporter-2 inhibitors (SGLT2i), dipeptidyl peptidase 4 inhibitors (DPP-4i) and didnt find an increased risk of diabetic retinopathy events with GLP-1 RAs or any of the other classes of antihyperglycemic medications

GLP-1 (Glucagon-Like Peptide-1) drugs are a class of medications used to treat Type 2 diabetes and for weight loss

Over the past years, the GST classification has constantly evolved, notably due to the increase of genomic data and to the presence of particular isoforms in a specific subset of organisms

Electrophysiological and c-Fos mapping studies in rodent models have demonstrated that amylin receptor activation in these regions inhibits gastric emptying, reduces meal size, and activates downstream satiety circuits projecting to the hypothalamic arcuate nucleus (Lutz et al., Physiology & Behavior, 2010)