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For instance, 5 g/mL of grape seed extract (GSE) inhibited d-galactose-induced apoptosis in vitro , but higher concentrations (50 and 100 g/mL) of GSE and GSPB2 for 24 h reduced the survival rates of hGC cells and KGN cell lines by approximately 20% and 50%, respectively (Barbe et al., 2019)

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6 , 7 As an isoform of GST, glutathione S-transferase P1 (GSTP1) is a significant regulator of cell signaling in response to stress, hypoxia, growth factors, and other stimuli