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Metabolic Transformation Study in vivo In this study, a simple and sensitive qualitative method based on liquid chromatography combined with Q-Exactive-Orbitrap tandem mass spectrometry in both positive and negative ion modes (detailed parameters of detection can be seen in above methods) was established for the determination of ASD and metabolites in rat samples obtained in excretion study, including the fecal homogenate, urine and bile

the Research Council of Norway FRIBIO Grant 197184