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Overuse leads to liver toxicity, particularly if combined with alcohol or other medications containing acetaminophen
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Chronic exposure has been associated with: Liver stress Immune suppression Increased inflammatory burden (14) Trichothecenes Often associated with Stachybotrys chartarum , trichothecenes can: Inhibit protein synthesis Disrupt mucosal immunity Intensify inflammatory signaling (15) Gliotoxin Produced by certain Aspergillus species, gliotoxin has immunosuppressive effects and may impair macrophage function and immune clearance (16)
robustness issues are discussed in Figures S26S27, S29 in File S1), and hence it was possible to use it reliably to deconstruct pathophysiological differences between individuals
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