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This may be due to the limited temporal window of our MRS measurements or could indicate that downstream mechanisms, such as AMPA receptor activation, neuroplastic signaling pathways (for example, BDNF or TrkB and ERK or mTOR) or effects in regions beyond the ACC, are more critical targets for mediating antidepressant response

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16 weeks 5 vials Lower vial count but larger draw volumes per dose 26 weeks 7 vials Standard Phase 2 duration 32 weeks 8 vials Phase 2 T2D study duration 68 weeks 17 vials Long-cycle planning matches REDEFINE 1 and 2 Insulin Syringes (U-100, 1 mL) One syringe per weekly injection