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Outcome measures included in trials to establish disease modification should include disease state assessment over 510 years while temporarily off all confounding symptomatic treatments (i.e., DBS and PD medications) with both appropriate clinical scales (i.e., UPDRS) as well as more innovative biomarkers 8,10,45

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For example, epidemiological studies have reported that co-administration of certain medicines may increase or reduce the risk of Chronic Obstructive Pulmonary Disease (COPD)