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Tumor Risk: The Dark Side of Growth Promoting Effects Cell proliferation and anti apoptotic effects IGF-1 LR3 activates the IGF-1R/PI3K/Akt pathway, inhibits the expression of key apoptotic proteins such as Caspase-3 and Bax, and promotes the synthesis of cell cycle proteins such as Cyclin D1, thereby accelerating cell proliferation

[Google Scholar] 32.Clements R.S., Jr., Darnell B

This description applies to a highly heterogeneous spectrum of pain syndromes presenting with a broad range of signs and symptoms, with various underlying pathophysiological mechanisms

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