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However, repeated or strenuous exercise bouts may transiently reduce plasma glutamine concentrations, particularly in individuals with limited muscle reserves, which has been proposed as one factor contributing to exercise-associated immune perturbations ( 4.2 Glutamineexercise interactions in redox regulation and inflammatory control during aging Progressive declines in antioxidant capacity and a chronic, smoldering inflammatory state are major contributors to functional impairments that emerge with advancing years ( Glutamine, a conditionally essential amino acid integral to glutathione synthesis, immune regulation, and cellular redox dynamics, has therefore gained attention as a potential nutritional support to enhance exercise-driven adaptations in older adults