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Moreover, EGFR serves as a significant therapeutic target in cancer, and mutations or overexpression of EGFR can lead to anti-apoptosis, angiogenesis, and metastasis

Gastrointestinal side effects, including nausea, vomiting, and diarrhea, are extremely common with GLP-1 therapy and may exacerbate nutritional deficits while directly contributing to feelings of unwellness and fatigue

Figure 1 2.3 Lipid antioxidant system in RA When lipid peroxides accumulate, cells can resist oxidation and prevent ferroptosis through various regulatory mechanisms, the most important of which is the antioxidant regulatory system composed of the cystine/glutamate antitransporter (System Xc-) and phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4) ( With the progress of research, in addition to the GPX4 antioxidant pathway, three other new pathways unrelated to GPX4 in ferroptosis have been identified: ferroptosis inhibition protein 1 (FSP1)/CoQ10, GTP cyclic hydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)