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References Wu G, Fang YZ, Yang S, Lupton JR, Turner ND

Mechanical Symptoms: What They Mean Mechanical symptoms are a red flag for structural damage that may require urgent care: Locking (inability to fully straighten or bend the knee) Catching or clicking during movement Recurrent swelling or giving way These signs often point to a displaced meniscus flap , such as a bucket-handle tear

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The proposed mechanisms are either antibody formation due to massive release of antigens following thyrocyte destruction or generation of new epitopes by a changed and more immunogenic conformation of the Tg molecule with high I 2 content