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One miRNA in particular, the miRNA-122, was shown in a cohort who had taken APAP to significantly increase before ALT levels rose.67 This finding was reaffirmed in another study that demonstrated a corresponding increase of serum miRNA-122 and miRNA-375, along with an increase in APAP protein adducts, all of which were also seen prior to ALT elevation.68 Urinary miRNA-375 was also detected at high levels in that study.68 Furthermore, that study had also enrolled children who had presented to the hospital with accidental APAP overdose, and thus applicability to the adult population may be better reserved for a time after other studies are completed with a greater adult population
C.Cadar AndoneB.CrinteaA.TatuC.et al (2024)
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Hypermethylation: causes and consequences in skeletal muscle myopathy
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