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Tirzepatide produced a mean weight reduction of 20.2% compared to 13.7% with semaglutide a statistically significant 6.5 percentage point difference

Common adverse effects encountered by users The common side effects of semaglutide mainly affect the gastrointestinal tract, which can lead to acute kidney injury in some cases, as well as potential risk factors for diabetic retinopathy

Some researchers extend a phase if they are still experiencing significant side effects at the current dose

Participants were randomized 1:1:1 to retatrutide 9 mg weekly, retatrutide 12 mg weekly, or placebo, with treatment lasting 68 weeks