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A conservative escalation for autoimmune patients might look like this: 2.5 mg weekly for six to eight weeks (instead of four), followed by 5 mg weekly for eight to twelve weeks with careful monitoring of both metabolic and autoimmune markers, then cautious escalation to 7.5 mg only if tolerated and if additional metabolic benefit is desired

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(Lond.) 483 , 597611 (1995)