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These mechanisms have been studied predominantly in in vitro cell culture models and animal research models

A meta-analysis that included 23 studies with 842 participants of randomized controlled trials that evaluated any biotic intervention in stage 3 to 4 CKD and also ESKD patients revealed that the biotics improved total antioxidative capacity and malondialdehyde and reduced the levels of IL-6

Regulation of ferroptosis Ferroptosis represents a distinct form of programmed cell death that diverges significantly from other established forms of cell death, including apoptosis, autophagy, and necrosis

Transcriptomic data suggested the involvement of MAPK and heat shock protein-necroptotic pathways in ZEA toxicity and the response to scutellarin (Yi et al., 2022)