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Some protocols use a 'loading' phase (higher dose for 35 days) followed by maintenance dosing (lower dose long-term), based on the hypothesis that initial synaptogenesis requires stronger signaling, while maintaining new synapses requires less

It can be unsafe to combine the 2, and this could cause side effects to get worse

A previous study of liraglutide on mice fed a diet lacking methionine and choline also found that GLP-1RAs not only could improve IR, but also reduce harmful ceramide/nerve sheath types, and reduce NAFLD inflammation and fibrosis (191)

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