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GH stimulation testing and random GH measurements have limited diagnostic utility for monitoring IGF-1 analogue use because exogenous LR3 suppresses pituitary GH output, creating a dissociation between GH and IGF-1 levels that may mislead interpretation [18]

Gene-Expression Modulation The most-cited modern work applied the Broad Institutes Connectivity Map to GHK, reporting that the peptide modulates expression of a large number of human genes with reviews describing shifts in several thousand genes at 1 M in cultured cells, including genes involved in DNA repair, antioxidant response, and inflammatory signalling

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