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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

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Eli Lilly has signalled intent to file with the FDA in the United States and the EMA in Europe after the TRIUMPH-1, 2, and 3 readouts

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