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As the condition progresses, you may notice: Fatigue and weakness Swelling in your feet, ankles, or legs Shortness of breath Nausea and vomiting Loss of appetite Changes in urination (more or less frequent, foamy, or bloody) Difficulty concentrating or confusion To diagnose kidney disease, your doctor may perform the following tests: Blood tests to measure waste product levels Urine tests to check for protein or blood Imaging tests, such as an ultrasound, to visualize your kidneys Kidney biopsy to determine the cause of your kidney problems Treatment for kidney disease depends on the underlying cause and the stage of the condition