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Zepbound is FDA-approved along with regular exercise and a reduced-calorie diet for chronic weight management in adults with an initial body mass index (BMI) of: 30 kg/m 2 or higher (obesity) 27 kg/m 2 or higher (overweight) with at least one weight-related condition such as high cholesterol, high blood pressure (hypertension), type 2 diabetes, heart disease, or obstructive sleep apnea Tirzepatide is the active ingredient in Zepbound