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Three landmark trials (Action to Control Cardiovascular Risk in Diabetes [ACCORD], Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation [ADVANCE], and Veterans Affairs Diabetes Trial [VADT]) were conducted to test the effects of near normalization of blood glucose on cardiovascular outcomes in individuals with long-standing type 2 diabetes and either known cardiovascular disease (CVD) or high cardiovascular risk

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They also inhibit enzymes indirectly involved in oxidative processes, such as phospholipase A2 (FLA2) [79], while stimulating others with recognized antioxidant properties, such as CAT and SOD [80]

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