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Inhibitors of PI3K and p42/44 mitogen-activated protein kinase (LY294002 and UO126), respectively as well as of p70S6K rapamycin abolished the GLP-1-induced infarct size limitation in rat hearts, suggesting that PI3K and p42/44 are involved in the myocardial protection elicited by GLP-1 [27, 69]

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Since the FDA removed semaglutide from the shortage list in February 2025, the legal basis for 503B compounding has been restricted

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