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The structural modification of this peptide includes an arginine substitution at position 3 and an extended amino acid sequence, which influences receptor binding affinity and reduces susceptibility to proteolytic enzymes in controlled experimental conditions

a 2025 literature-and-patent review in Pharmaceuticals summarizes its multifunctional, mostly-preclinical profile (PMC11859134)

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Empirical medical treatments such as human menopausal gonadotrophin (hMG)/human chorionic gonadotrophin (hCG), androgen, antioestrogens (clomiphene and tamoxifen), prolactin inhibitors (bromocriptine), and steroids have been used