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Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority

Diabetes, 64(7), 25132525

Curcumin Reported dosage: 24.5 grams daily (but formulations vary) Curcumin is a major active constituent of turmeric, a rhizome used for millennia as a traditional culinary ingredient and in Ayurvedic medicine as a remedy for health concerns such as musculoskeletal, digestive, and skin conditions (Aggarwal 2007)

In our clinic, we address nausea as a clinical problem the same week it comes up, and most patients are able to continue treatment with appropriate adjustments