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doi: 10.3389/fnins.2025.1597170 Received 20 March 2025 Accepted 18 June 2025 Published 15 July 2025 Volume 19 - 2025 Edited by Koichi Yuki, Harvard Medical School, United States Reviewed by Abraham Jacob Al-Ahmad, Jerry H

On-Treatment Analysis (If Everyone Stayed on Max Dose): CagriSema achieved 22.7% weight loss using trial-product estimand (assumes perfect adherence at max dose)

While NOS3, FOXO3, and SOD2 genotypes set biological baselines with limited nutritional modifiability, MTHFR functional consequences are substantially responsive to the folate and B vitamin nutritional environment: 5-MTHF (active methylfolate) vs

and 4, step 4: adding 0.1% of active carbon for injection, and stirring for 10 minutes