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Hypertension and dyslipidemia were defined based on physician diagnosis and/or relevant pharmacotherapy

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45 , 50 Figure 6Evidence Network Change in A1C at 26 Weeks for NMA of Semaglutide Versus Sulfonylureas FIGURE CONTAINED CONFIDENTIAL INFORMATION AND WAS REDACTED AT THE REQUEST OF THE MANUFACTURER Figure 7Evidence Network for Change in A1C at 52 Weeks for NMA of Semaglutide Versus Sulfonylureas FIGURE CONTAINED CONFIDENTIAL INFORMATION AND WAS REDACTED AT THE REQUEST OF THE MANUFACTURER Table 64NMA Results for Change in A1C for SEM Versus Sulfonylureas Table 65NMA Results for Change from Baseline in Weight (kg) for Sulfonylureas Critical Appraisal The manufacturer submitted three NMAs that evaluated semaglutide as add-on therapy to metformin, with comparisons made to different drug classes: other glucagon-like peptide 1 (GLP-1) agonists, 44 SGLT2 inhibitors, 45 and sulfonylureas

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