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Mitochondrial Biogenesis Slu-pp-332 and 5-Amino-1MQ are investigated for their roles in stimulating new mitochondrial creation and improving cellular respiration, supporting enhanced energy efficiency

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For patients with coexisting depression and obesity, naltrexone/bupropion can be considered first-line pharmacotherapy due to the antidepressant properties of bupropion, which functions as a noradrenalin and dopamine reuptake inhibitor (119)

When patients respond inadequately to one GLP-1 agent, data now supports switching to or adding the complementary GLP-1/GIP dual agonist (tirzepatide) rather than introducing a second drug class like phentermine