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Through the production of metabolites such as short-chain fatty acids, indole derivatives, and bile acidrelated molecules, and via receptor pathways including FFAR2/3, FXR, and TGR5, the microbiota modulates incretin secretion, tissue insulin sensitivity, immune tone, and the integrity of the intestinal epithelial barrier

There seems to be a problem with overproduction of the keratin part of the skin called hyper keratinisation which causes thickening of the skin