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Finally, the present study found, by assessing the reliability of subgroup analyses, that almost all subgroup analyses were unreliable, limited by the fact that both the number of included studies and the sample size were small

These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58

The BBB and BCSFB are formed by tight junctions of brain capillary endothelial cells and choroid plexus epithelial cells, respectively, and serve to regulate the supply of essential nutrients into the brain/CSF and the elimination of xenobiotics and endogenous metabolites from the brain/CSF via various transport systems such as transporters [5, 6]

El uso seguro y eficaz de estos medicamentos requiere una evaluacin individualizada de riesgo-beneficio