10 Conclusions and clinical take-home messages 10.1 Main findings: certainties amidst uncertainties Synthesizing the current evidence, the information architecture regarding GLP-1RAs in PCOS fertility management exhibits a characteristic gradient: robust metabolic evidence, hypothesis-generating reproductive findings, and a gray zone of safety. Robust metabolic benefit: in overweight or obese PCOS phenotypes, evidence for the improvement of metabolic endpointsincluding body weight, central adiposity, and IRis consistently positive, facilitating the establishment of actionable therapeutic goals (e.g., reaching clinically significant weight-loss thresholds and optimizing IR markers)
doi:10.1016/j.mam.2008.05.005 Lu SC (2013) Glutathione synthesis
It is important that people who are prescribed GLP-1 analogues continue to take them and contact their diabetes team if they have any concerns. References [1] US Food and Drug Adminstration
Nevertheless, a deficiency can occur under certain conditions, such as acute gastrointestinal problems like diarrhea or vomiting, kidney disease , chronic alcohol consumption or regular use of medication such as diuretics
