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Antioxidants enhance 3-AR-triggered mitochondrial ROS production, suggesting that chronic supplementation of antioxidants could indeed generate an elevation in oxidative stress associated with mitochondrial dysfunction in adipocyte [109]

Some have reported that serum MMA and homocysteine levels increase with age and the prevalence of elevated MMA and homocysteine levels is higher than the prevalence of low vitamin B 12 or clinically evident vitamin B 12 deficiency in the elderly.19 20 21 22 In this regard, using the assay for metabolites alone may result in overdiagnosis and overtreatment

The importance of early detection of endotoxemia

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