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Research has identified several contributing mechanisms: dysregulated innate immune signalling, oxidative stress from reactive oxygen species damaging skin cells, and impaired barrier function that leaves the skin more reactive to triggers it would otherwise tolerate

Instead, pre-stroke weight loss is an upstream crucial mechanism in this respect

J Psychopharmacol 12 : 5467

A oligomers exacerbate this process, producing reactive aldehydes like 4-hydroxy-2-nonenal (HNE) that damage proteins and contribute to neurodegeneration [172]