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Cells were transduced with five shRNAs per gene

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*Correspondence: Michele Marin, [email protected] This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Originally developed for type 2 diabetes management under the brand name Ozempic in 2017, it received approval for weight loss as Wegovy in 2021 after clinical trials demonstrated remarkable efficacy