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Amelanotic forms may require use of immunohistochemical identification: S-100 protein, HMB-45, Melan-A expression Diagnosis Biopsy High index of suspicion Differential Diagnosis Mucosal nevus Extrinsic pigmentation Melanoacanthoma Kaposis sarcoma Vascular malformation Amalgam tattoo Mucosal melanotic macule Treatment Surgical excision Marginal parameters related to depth of invasion and presence of lateral growth Wide surgical margins

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Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo