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Intranasal delivery may: Support antioxidant defenses within the CNS Help address brain fog and cognitive fatigue Complement other neuro-targeted tools such as NAD nasal spray or theanine nasal spray with GABA In surveys of people with Parkinsons using intranasal glutathione, roughly a quarter to one-third reported improvements in symptoms and energy

Classical antifolate drugs, including methotrexate (targeting DHFR) [153] and fluoropyrimidine agents (targeting TYMS) [154], induce cell death in rapidly proliferating malignancies by specifically inhibiting key enzymes in 1 C metabolism, thereby depleting nucleotide pools and causing replication stress [101]

Some indications are that higher doses lead to more severe side effects

Studies in animals have shown that it might be able to reduce symptoms of anxiety and depression