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Despite the lack of definitive evidence from well-conducted randomized trials on the effectiveness of regular daily omega-3 PUFA supplementation in mitigating migraine symptoms for those with episodic or chronic migraines, the overall positive effects in different areas (e.g., immune, neurological, psychiatric, and cardiovascular) suggest that omega-3 PUFAs could be considered as potential health supplements or adjuncts in migraine prevention and treatment

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While the direct treatment allows contact with the active plasma zone, indirect treatment typically means contact of the treated object with an effluent of the plasma, thus with only long-living species 4